| Transactions |
| Date | Team | Player | Type | OthTm | EffDate | When |
| 3/26/2011 | Bal | Lohse | Acquired via trade | SF |   | After |
| 3/26/2011 | Bal | Lowell | Traded away | Sea |   | After |
| 3/26/2011 | Bal | McCutchen,D | Traded away | SF |   | After |
| 3/26/2011 | Bal | Rowland-Smith | Acquired via trade | Sea |   | After |
| 3/26/2011 | Bos | Bloomquist | Traded away | Cle |   | After |
| 3/26/2011 | Bos | Duke | Acquired via trade | NYY |   | After |
| 3/26/2011 | Bos | Iwamura | Traded away | NYY |   | After |
| 3/26/2011 | Bos | Robertson,N | Acquired via trade | Cle |   | After |
| 3/26/2011 | ChC | Eveland | Acquired via trade | StL |   | After |
| 3/26/2011 | ChC | Rowand | Traded away | StL |   | After |
| 3/26/2011 | Cin | Atilano | Acquired via trade | KC |   | After |
| 3/26/2011 | Cin | Feliz,P | Traded away | KC |   | After |
| 3/26/2011 | Cin | Harden | Acquired via trade | Phi |   | After |
| 3/26/2011 | Cin | Helms | Traded away | Phi |   | After |
| 3/26/2011 | Cle | Bloomquist | Acquired via trade | Bos |   | After |
| 3/26/2011 | Cle | Robertson,N | Traded away | Bos |   | After |
| 3/26/2011 | Det | Blackburn | Acquired via trade | SF |   | After |
| 3/26/2011 | Det | Davies | Acquired via trade | SF |   | After |
| 3/26/2011 | Det | Rogers,E | Traded away | SF |   | After |
| 3/26/2011 | Det | Sweeney,R | Traded away | SF |   | After |
| 3/26/2011 | KC | Atilano | Traded away | Cin |   | After |
| 3/26/2011 | KC | Feliz,P | Acquired via trade | Cin |   | After |
| 3/26/2011 | LA | Moehler | Acquired via trade | Sea |   | After |
| 3/26/2011 | LA | Wilson,Ja | Traded away | Sea |   | After |
| 3/26/2011 | NYM | Suppan | Acquired via trade | Pit |   | After |
| 3/26/2011 | NYM | Texeira | Traded away | Pit |   | After |
| 3/26/2011 | NYY | Duke | Traded away | Bos |   | After |
| 3/26/2011 | NYY | Iwamura | Acquired via trade | Bos |   | After |
| 3/26/2011 | Phi | Harden | Traded away | Cin |   | After |
| 3/26/2011 | Phi | Helms | Acquired via trade | Cin |   | After |
| 3/26/2011 | Pit | Cabrera,E | Traded away | Tex |   | After |
| 3/26/2011 | Pit | Hendrickson | Acquired via trade | Tex |   | After |
| 3/26/2011 | Pit | Suppan | Traded away | NYM |   | After |
| 3/26/2011 | Pit | Texeira | Acquired via trade | NYM |   | After |
| 3/26/2011 | Pit | Wellemeyer | Acquired via trade | Tex |   | After |
| 3/26/2011 | Pit | Young,E | Traded away | Tex |   | After |
| 3/26/2011 | Sea | Lowell | Acquired via trade | Bal |   | After |
| 3/26/2011 | Sea | Moehler | Traded away | LA |   | After |
| 3/26/2011 | Sea | Rowland-Smith | Traded away | Bal |   | After |
| 3/26/2011 | Sea | Wilson,Ja | Acquired via trade | LA |   | After |
| 3/26/2011 | SF | Blackburn | Traded away | Det |   | After |
| 3/26/2011 | SF | Davies | Traded away | Det |   | After |
| 3/26/2011 | SF | Lohse | Traded away | Bal |   | After |
| 3/26/2011 | SF | McCutchen,D | Acquired via trade | Bal |   | After |
| 3/26/2011 | SF | Rogers,E | Acquired via trade | Det |   | After |
| 3/26/2011 | SF | Sweeney,R | Acquired via trade | Det |   | After |
| 3/26/2011 | StL | Eveland | Traded away | ChC |   | After |
| 3/26/2011 | StL | Rowand | Acquired via trade | ChC |   | After |
| 3/26/2011 | Tex | Cabrera,E | Acquired via trade | Pit |   | After |
| 3/26/2011 | Tex | Hendrickson | Traded away | Pit |   | After |
| 3/26/2011 | Tex | Wellemeyer | Traded away | Pit |   | After |
| 3/26/2011 | Tex | Young,E | Acquired via trade | Pit |   | After |
| 4/7/2011 | LA | Karstens | Promoted to active roster |   |   | Before |
| 4/7/2011 | LA | Pavano | Placed on disabled list |   | 4/7/2011 | Before |
| 4/10/2011 | LA | Fister | Placed on disabled list |   | 4/10/2011 | Before |
| 4/10/2011 | LA | Lopez,R | Promoted to active roster |   |   | Before |
| 4/17/2011 | Cle | LeBlanc | Promoted to active roster |   |   | Before |
| 4/17/2011 | Cle | Scherzer | Placed on disabled list |   | 4/17/2011 | Before |
| 4/18/2011 | NYY | Bourjos | Promoted to active roster |   |   | Before |
| 4/18/2011 | NYY | Cruz,N | Placed on disabled list |   | 4/18/2011 | Before |
| 4/18/2011 | SF | Aviles | Placed on disabled list |   | 4/18/2011 | Before |
| 4/18/2011 | SF | Lugo | Promoted to active roster |   |   | Before |
| 4/22/2011 | LA | Lopez,R | Demoted to reserve roster |   |   | Before |
| 4/22/2011 | LA | Pavano | Activated from disabled list |   |   | Before |
| 4/24/2011 | ChC | Lopez,F | Placed on disabled list |   | 4/24/2011 | Before |
| 4/24/2011 | ChC | Sanchez,Ang | Promoted to active roster |   |   | Before |
| 4/24/2011 | Det | Bartlett | Placed on disabled list |   | 4/24/2011 | Before |
| 4/24/2011 | Det | Nady | Promoted to active roster |   |   | Before |
| 4/25/2011 | LA | Fister | Activated from disabled list |   |   | Before |
| 4/25/2011 | LA | Karstens | Demoted to reserve roster |   |   | Before |
| 4/26/2011 | KC | Masterson | Placed on disabled list |   | 4/26/2011 | Before |
| 4/26/2011 | KC | McDonald,Ja | Promoted to active roster |   |   | Before |
| 5/2/2011 | Cle | LeBlanc | Demoted to reserve roster |   |   | Before |
| 5/2/2011 | Cle | Scherzer | Activated from disabled list |   |   | Before |
| 5/9/2011 | Cle | Giambi | Promoted to active roster |   |   | Before |
| 5/9/2011 | Cle | Ortiz,D | Placed on disabled list |   | 5/9/2011 | Before |
| 5/9/2011 | Cle | Perry | Promoted to active roster |   |   | Before |
| 5/9/2011 | Cle | Sanabia | Placed on disabled list |   | 5/9/2011 | Before |
| 5/10/2011 | CWS | Badenhop | Placed on disabled list |   | 5/10/2011 | Before |
| 5/10/2011 | CWS | Qualls | Promoted to active roster |   |   | Before |
| 5/11/2011 | KC | Masterson | Activated from disabled list |   |   | Before |
| 5/11/2011 | KC | McDonald,Ja | Demoted to reserve roster |   |   | Before |
| 5/12/2011 | Cle | LeBlanc | Promoted to active roster |   |   | Before |
| 5/12/2011 | Cle | Scherzer | Placed on disabled list |   | 5/12/2011 | Before |
| 5/13/2011 | NYY | Bourjos | Demoted to reserve roster |   |   | Before |
| 5/13/2011 | NYY | Cruz,N | Activated from disabled list |   |   | Before |
| 5/14/2011 | LA | Karstens | Promoted to active roster |   |   | Before |
| 5/14/2011 | LA | Marcum | Placed on disabled list |   | 5/14/2011 | Before |
| 5/16/2011 | SF | Rogers,E | Placed on disabled list |   | 5/16/2011 | Before |
| 5/16/2011 | SF | Tallet | Promoted to active roster |   |   | Before |
| 5/20/2011 | Atl | DeWitt | Promoted to active roster |   |   | Before |
| 5/20/2011 | Atl | Johnson,C | Placed on disabled list |   | 5/20/2011 | Before |
| 5/20/2011 | Det | Bartlett | Activated from disabled list |   |   | Before |
| 5/20/2011 | Det | Nady | Demoted to reserve roster |   |   | Before |
| 5/20/2011 | Pit | Hudson,O | Placed on disabled list |   | 5/20/2011 | Before |
| 5/20/2011 | Pit | Punto | Promoted to active roster |   |   | Before |
| 5/20/2011 | SF | Aviles | Activated from disabled list |   |   | Before |
| 5/20/2011 | SF | Lugo | Demoted to reserve roster |   |   | Before |
| 5/21/2011 | ChC | Lopez,F | Activated from disabled list |   |   | Before |
| 5/21/2011 | ChC | Sanchez,Ang | Demoted to reserve roster |   |   | Before |
| 5/24/2011 | Oak | Kershaw | Placed on disabled list |   | 5/24/2011 | Before |
| 5/24/2011 | Oak | Leake | Promoted to active roster |   |   | Before |
| 5/25/2011 | Atl | Buchholz,C | Placed on disabled list |   | 5/25/2011 | Before |
| 5/25/2011 | Atl | Fukudome | Promoted to active roster |   |   | Before |
| 5/25/2011 | Atl | Herndon | Demoted to reserve roster |   |   | Before |
| 5/25/2011 | Atl | Herndon | Promoted to active roster |   |   | Before |
| 5/26/2011 | Cle | French | Promoted to active roster |   |   | Before |
| 5/26/2011 | Cle | Giambi | Demoted to reserve roster |   |   | Before |
| 5/26/2011 | Cle | Medlen | Placed on disabled list |   | 5/26/2011 | Before |
| 5/26/2011 | Cle | Ortiz,D | Activated from disabled list |   |   | Before |
| 5/26/2011 | CWS | Badenhop | Activated from disabled list |   |   | Before |
| 5/26/2011 | CWS | Qualls | Demoted to reserve roster |   |   | Before |
| 5/27/2011 | Cle | French | Demoted to reserve roster |   |   | Before |
| 5/27/2011 | Cle | Perry | Demoted to reserve roster |   |   | Before |
| 5/27/2011 | Cle | Sanabia | Activated from disabled list |   |   | Before |
| 5/27/2011 | Cle | Scherzer | Activated from disabled list |   |   | Before |
| 5/30/2011 | Cle | Diaz,M | Traded away | Hou |   | After |
| 5/30/2011 | Cle | Infante,O | Traded away | Hou |   | After |
| 5/30/2011 | Cle | Sanchez,F | Acquired via trade | Hou |   | After |
| 5/30/2011 | Cle | Smoak | Acquired via trade | Hou |   | After |
| 5/30/2011 | Hou | Diaz,M | Acquired via trade | Cle |   | After |
| 5/30/2011 | Hou | Infante,O | Acquired via trade | Cle |   | After |
| 5/30/2011 | Hou | Sanchez,F | Traded away | Cle |   | After |
| 5/30/2011 | Hou | Smoak | Traded away | Cle |   | After |
| 5/31/2011 | SF | Rogers,E | Activated from disabled list |   |   | Before |
| 5/31/2011 | SF | Tallet | Demoted to reserve roster |   |   | Before |
| 6/1/2011 | NYY | Bailey,H | Promoted to active roster |   |   | Before |
| 6/1/2011 | NYY | Slowey | Placed on disabled list |   | 6/1/2011 | Before |
| 6/3/2011 | LA | Karstens | Demoted to reserve roster |   |   | Before |
| 6/3/2011 | LA | Marcum | Activated from disabled list |   |   | Before |
| 6/4/2011 | Oak | Leake | Placed on disabled list |   | 6/4/2011 | Before |
| 6/4/2011 | Oak | Niese | Promoted to active roster |   |   | Before |
| 6/8/2011 | NYY | Garza | Demoted to reserve roster |   |   | Before |
| 6/8/2011 | NYY | Vazquez | Promoted to active roster |   |   | Before |
| 6/8/2011 | Oak | Kershaw | Activated from disabled list |   |   | Before |
| 6/8/2011 | Oak | Niese | Demoted to reserve roster |   |   | Before |
| 6/13/2011 | Atl | DeWitt | Demoted to reserve roster |   |   | Before |
| 6/13/2011 | Atl | Johnson,C | Activated from disabled list |   |   | Before |
| 6/13/2011 | Pit | Hudson,O | Activated from disabled list |   |   | Before |
| 6/13/2011 | Pit | Punto | Demoted to reserve roster |   |   | Before |
| 6/14/2011 | Cle | Guillen,J | Demoted to reserve roster |   |   | Before |
| 6/14/2011 | Cle | Smoak | Promoted to active roster |   |   | Before |
| 6/14/2011 | StL | Baker,S | Demoted to reserve roster |   |   | Before |
| 6/14/2011 | StL | Harang | Promoted to active roster |   |   | Before |
| 6/18/2011 | Bal | Belliard | Promoted to active roster |   |   | Before |
| 6/18/2011 | Bal | Furcal | Placed on disabled list |   | 6/18/2011 | Before |
| 6/19/2011 | Atl | Buchholz,C | Activated from disabled list |   |   | Before |
| 6/19/2011 | Atl | Fukudome | Demoted to reserve roster |   |   | Before |
| 6/19/2011 | Oak | Leake | Activated from disabled list |   |   | Before |
| 6/19/2011 | Oak | Leake | Demoted to reserve roster |   |   | Before |
| 6/20/2011 | Cle | LeBlanc | Demoted to reserve roster |   |   | Before |
| 6/20/2011 | Cle | Medlen | Activated from disabled list |   |   | Before |
| 6/21/2011 | SF | Hawpe | Promoted to active roster |   |   | Before |
| 6/21/2011 | SF | Sweeney,R | Placed on disabled list |   | 6/21/2011 | Before |
| 6/22/2011 | Hou | Beckett | Promoted to active roster |   |   | Before |
| 6/22/2011 | Hou | Gallardo | Placed on disabled list |   | 6/22/2011 | Before |
| 6/23/2011 | Atl | Fukudome | Promoted to active roster |   |   | Before |
| 6/23/2011 | Atl | Ramirez,Man | Placed on disabled list |   | 6/23/2011 | Before |
| 6/25/2011 | Bal | Bard,J | Promoted to active roster |   |   | Before |
| 6/25/2011 | Bal | Kendall | Placed on disabled list |   | 6/25/2011 | Before |
| 6/25/2011 | Bos | Chen | Promoted to active roster |   |   | Before |
| 6/25/2011 | Bos | Hunter,Tom | Placed on disabled list |   | 6/25/2011 | Before |
| 6/27/2011 | LA | Maier | Promoted to active roster |   |   | Before |
| 6/27/2011 | LA | Michaels | Placed on disabled list |   | 6/27/2011 | Before |
| 6/28/2011 | Cle | Enright | Demoted to reserve roster |   |   | Before |
| 6/28/2011 | Cle | LeBlanc | Promoted to active roster |   |   | Before |
| 7/1/2011 | NYY | Slowey | Activated from disabled list |   |   | Before |
| 7/1/2011 | NYY | Slowey | Demoted to reserve roster |   |   | Before |
| 7/2/2011 | Phi | Jones,G | Promoted to active roster |   |   | Before |
| 7/2/2011 | Phi | Morales,K | Placed on disabled list |   | 7/2/2011 | Before |
| 7/4/2011 | Oak | LaPorta | Promoted to active roster |   |   | Before |
| 7/4/2011 | Oak | Scott | Placed on disabled list |   | 7/4/2011 | Before |
| 7/5/2011 | Cle | Escobar,Y | Placed on disabled list |   | 7/5/2011 | Before |
| 7/5/2011 | Cle | Wilson,Jo | Promoted to active roster |   |   | Before |
| 7/6/2011 | NYY | Bailey,H | Demoted to reserve roster |   |   | Before |
| 7/6/2011 | NYY | Slowey | Promoted to active roster |   |   | Before |
| 7/11/2011 | Atl | Fukudome | Demoted to reserve roster |   |   | Before |
| 7/11/2011 | Atl | Ramirez,Man | Activated from disabled list |   |   | Before |
| 7/11/2011 | Bal | Bard,J | Demoted to reserve roster |   |   | Before |
| 7/11/2011 | Bal | Kendall | Activated from disabled list |   |   | Before |
| 7/11/2011 | Sea | Cabrera,Me | Promoted to active roster |   |   | Before |
| 7/11/2011 | Sea | Colvin | Demoted to reserve roster |   |   | Before |
| 7/11/2011 | SF | Bay | Promoted to active roster |   |   | Before |
| 7/11/2011 | SF | Burnett,AJ | Promoted to active roster |   |   | Before |
| 7/11/2011 | SF | Cain,M | Demoted to reserve roster |   |   | Before |
| 7/11/2011 | SF | Coghlan | Promoted to active roster |   |   | Before |
| 7/11/2011 | SF | Cueto | Demoted to reserve roster |   |   | Before |
| 7/11/2011 | SF | Hawpe | Demoted to reserve roster |   |   | Before |
| 7/11/2011 | SF | Hughes,P | Demoted to reserve roster |   |   | Before |
| 7/11/2011 | SF | Lannan | Promoted to active roster |   |   | Before |
| 7/11/2011 | SF | Norris | Demoted to reserve roster |   |   | Before |
| 7/11/2011 | SF | Norris | Promoted to active roster |   |   | Before |
| 7/11/2011 | SF | Norris | Promoted to active roster |   |   | Before |
| 7/11/2011 | SF | Venable | Demoted to reserve roster |   |   | Before |
| 7/14/2011 | ChC | Napoli | Placed on disabled list |   | 7/14/2011 | Before |
| 7/14/2011 | ChC | Navarro,D | Promoted to active roster |   |   | Before |
| 7/15/2011 | Bos | Chen | Demoted to reserve roster |   |   | Before |
| 7/15/2011 | Bos | Hunter,Tom | Activated from disabled list |   |   | Before |
| 7/16/2011 | LA | Maier | Demoted to reserve roster |   |   | Before |
| 7/16/2011 | LA | Michaels | Activated from disabled list |   |   | Before |
| 7/17/2011 | Hou | Gallardo | Activated from disabled list |   |   | Before |
| 7/17/2011 | Hou | Matusz | Demoted to reserve roster |   |   | Before |
| 7/17/2011 | Phi | Jones,G | Demoted to reserve roster |   |   | Before |
| 7/17/2011 | Phi | Morales,K | Activated from disabled list |   |   | Before |
| 7/19/2011 | Bal | Belliard | Demoted to reserve roster |   |   | Before |
| 7/19/2011 | Bal | Furcal | Activated from disabled list |   |   | Before |
| 7/20/2011 | Cin | Ellis,M | Placed on disabled list |   | 7/20/2011 | Before |
| 7/20/2011 | Cin | Guzman | Promoted to active roster |   |   | Before |
| 7/21/2011 | Atl | DeWitt | Promoted to active roster |   |   | Before |
| 7/21/2011 | Atl | Howard | Placed on disabled list |   | 7/21/2011 | Before |
| 7/21/2011 | Cin | Arrieta | Promoted to active roster |   |   | Before |
| 7/21/2011 | Cin | Kuroda | Placed on disabled list |   | 7/21/2011 | Before |
| 7/21/2011 | SF | Bay | Demoted to reserve roster |   |   | Before |
| 7/21/2011 | SF | Sweeney,R | Activated from disabled list |   |   | Before |
| 7/25/2011 | LA | Maier | Promoted to active roster |   |   | Before |
| 7/25/2011 | LA | Willingham | Placed on disabled list |   | 7/25/2011 | Before |
| 7/25/2011 | NYY | Cabrera,A | Placed on disabled list |   | 7/25/2011 | Before |
| 7/25/2011 | NYY | Escobar,A | Promoted to active roster |   |   | Before |
| 7/25/2011 | Pit | Hudson,O | Placed on disabled list |   | 7/25/2011 | Before |
| 7/25/2011 | Pit | Punto | Promoted to active roster |   |   | Before |
| 7/26/2011 | Cle | Escobar,Y | Activated from disabled list |   |   | Before |
| 7/26/2011 | Cle | Wilson,Jo | Demoted to reserve roster |   |   | Before |
| 7/28/2011 | Tex | Floyd | Placed on disabled list |   | 7/28/2011 | Before |
| 7/28/2011 | Tex | Takahashi | Promoted to active roster |   |   | Before |
| 8/1/2011 | CWS | Garcia,F | Promoted to active roster |   |   | Before |
| 8/1/2011 | CWS | Vargas,J | Placed on disabled list |   | 8/1/2011 | Before |
| 8/1/2011 | Oak | LaPorta | Demoted to reserve roster |   |   | Before |
| 8/1/2011 | Oak | Scott | Activated from disabled list |   |   | Before |
| 8/2/2011 | Bal | Bard,J | Promoted to active roster |   |   | Before |
| 8/2/2011 | Bal | Kendall | Placed on disabled list |   | 8/2/2011 | Before |
| 8/5/2011 | ChC | Napoli | Activated from disabled list |   |   | Before |
| 8/5/2011 | ChC | Navarro,D | Demoted to reserve roster |   |   | Before |
| 8/5/2011 | Cin | Arrieta | Demoted to reserve roster |   |   | Before |
| 8/5/2011 | Cin | Kuroda | Activated from disabled list |   |   | Before |
| 8/7/2011 | Hou | Bourjos | Acquired via trade | NYY |   | After |
| 8/7/2011 | Hou | Soriano,R | Traded away | NYY |   | After |
| 8/7/2011 | NYY | Bourjos | Traded away | Hou |   | After |
| 8/7/2011 | NYY | Soriano,R | Acquired via trade | Hou |   | After |
| 8/8/2011 | Atl | Crosby | Demoted to reserve roster |   |   | Before |
| 8/8/2011 | Atl | Crosby | Promoted to active roster |   |   | Before |
| 8/8/2011 | Atl | Howard | Activated from disabled list |   |   | Before |
| 8/8/2011 | Atl | Lowrie | Demoted to reserve roster |   |   | Before |
| 8/8/2011 | Hou | Boggs,M | Promoted to active roster |   |   | Before |
| 8/8/2011 | Hou | Bourjos | Promoted to active roster |   |   | Before |
| 8/8/2011 | Hou | Fowler | Demoted to reserve roster |   |   | Before |
| 8/8/2011 | NYY | Wright,J | Demoted to reserve roster |   |   | Before |
| 8/9/2011 | Hou | Beckett | Placed on disabled list |   | 8/10/2011 | Before |
| 8/9/2011 | Hou | Matusz | Promoted to active roster |   |   | Before |
| 8/9/2011 | LA | Maier | Demoted to reserve roster |   |   | Before |
| 8/9/2011 | LA | Willingham | Activated from disabled list |   |   | Before |
| 8/10/2011 | Bal | Cook | Promoted to active roster |   |   | Before |
| 8/10/2011 | Bal | Jurrjens | Placed on disabled list |   | 8/10/2011 | Before |
| 8/13/2011 | Phi | Garcia,J | Placed on disabled list |   | 8/13/2011 | Before |
| 8/13/2011 | Phi | Talbot | Promoted to active roster |   |   | Before |
| 8/14/2011 | Det | Olivo | Placed on disabled list |   | 8/14/2011 | Before |
| 8/14/2011 | Det | Whiteside | Promoted to active roster |   |   | Before |
| 8/15/2011 | Bal | Cook | Placed on disabled list |   | 8/15/2011 | Before |
| 8/15/2011 | Bal | Rowland-Smith | Promoted to active roster |   |   | Before |
| 8/16/2011 | CWS | Garcia,F | Demoted to reserve roster |   |   | Before |
| 8/16/2011 | CWS | Vargas,J | Activated from disabled list |   |   | Before |
| 8/17/2011 | Cin | Ellis,M | Activated from disabled list |   |   | Before |
| 8/17/2011 | Cin | Guzman | Demoted to reserve roster |   |   | Before |
| 8/17/2011 | Tex | Floyd | Activated from disabled list |   |   | Before |
| 8/17/2011 | Tex | Takahashi | Demoted to reserve roster |   |   | Before |
| 8/21/2011 | Pit | Hudson,O | Activated from disabled list |   |   | Before |
| 8/21/2011 | Pit | Punto | Demoted to reserve roster |   |   | Before |
| 8/22/2011 | Bal | Bard,J | Demoted to reserve roster |   |   | Before |
| 8/22/2011 | Bal | Kendall | Activated from disabled list |   |   | Before |
| 8/22/2011 | NYY | Garza | Promoted to active roster |   |   | Before |
| 8/22/2011 | NYY | Slowey | Demoted to reserve roster |   |   | Before |
| 8/22/2011 | SF | Cain,M | Promoted to active roster |   |   | Before |
| 8/22/2011 | SF | Nolasco | Demoted to reserve roster |   |   | Before |
| 8/23/2011 | NYY | Cabrera,A | Activated from disabled list |   |   | Before |
| 8/23/2011 | NYY | Escobar,A | Demoted to reserve roster |   |   | Before |
| 8/24/2011 | Cle | Rodriguez,A | Placed on disabled list |   | 8/24/2011 | Before |
| 8/24/2011 | Cle | Wilson,Jo | Promoted to active roster |   |   | Before |
| 8/30/2011 | Bal | Jurrjens | Activated from disabled list |   |   | Before |
| 8/30/2011 | Bal | Rowland-Smith | Demoted to reserve roster |   |   | Before |
| 8/31/2011 | CWS | Garcia,F | Promoted to active roster |   |   | Before |
| 8/31/2011 | CWS | Vargas,J | Placed on disabled list |   | 8/31/2011 | Before |
| 9/3/2011 | Cin | Arrieta | Promoted to active roster |   |   | Before |
| 9/3/2011 | Cin | Pettitte | Placed on disabled list |   | 9/3/2011 | Before |
| 9/4/2011 | Bal | Cook | Activated from disabled list |   |   | Before |
| 9/4/2011 | Bal | Cook | Demoted to reserve roster |   |   | Before |
| 9/5/2011 | Atl | Fukudome | Promoted to active roster |   |   | Before |
| 9/5/2011 | Atl | Happ | Demoted to reserve roster |   |   | Before |
| 9/5/2011 | Atl | Janssen | Demoted to reserve roster |   |   | Before |
| 9/5/2011 | Atl | Kendrick,K | Promoted to active roster |   |   | Before |
| 9/5/2011 | CWS | Garcia,F | Placed on disabled list |   | 9/5/2011 | Before |
| 9/5/2011 | Hou | Boggs,M | Demoted to reserve roster |   |   | Before |
| 9/5/2011 | Hou | Boggs,M | Promoted to active roster |   |   | Before |
| 9/7/2011 | LA | Cantu | Promoted to active roster |   |   | Before |
| 9/7/2011 | LA | Tulowitzki | Placed on disabled list |   | 9/7/2011 | Before |
| 9/8/2011 | Cle | Rodriguez,A | Activated from disabled list |   |   | Before |
| 9/8/2011 | Cle | Wilson,Jo | Demoted to reserve roster |   |   | Before |
| 9/9/2011 | Bal | Belliard | Promoted to active roster |   |   | Before |
| 9/9/2011 | Bal | Nix,J | Placed on disabled list |   | 9/9/2011 | Before |
| 9/9/2011 | Det | Olivo | Activated from disabled list |   |   | Before |
| 9/9/2011 | Det | Whiteside | Demoted to reserve roster |   |   | Before |
| 9/9/2011 | Hou | Beckett | Activated from disabled list |   |   | Before |
| 9/9/2011 | Hou | Hamels | Demoted to reserve roster |   |   | Before |
| 9/12/2011 | Phi | Garcia,J | Activated from disabled list |   |   | Before |
| 9/12/2011 | Phi | Talbot | Demoted to reserve roster |   |   | Before |
| 9/14/2011 | Atl | Crosby | Promoted to active roster |   |   | Before |
| 9/14/2011 | Atl | Utley | Placed on disabled list |   | 9/14/2011 | Before |
| 9/15/2011 | CWS | Vargas,J | Activated from disabled list |   |   | Before |
| 9/16/2011 | Hou | Gallardo | Placed on disabled list |   | 9/16/2011 | Before |
| 9/16/2011 | Hou | Hamels | Promoted to active roster |   |   | Before |
| 9/19/2011 | ChC | Kennedy,I | Placed on disabled list |   | 9/19/2011 | Before |
| 9/19/2011 | ChC | Stammen | Promoted to active roster |   |   | Before |
| 9/19/2011 | Sea | McLouth | Demoted to reserve roster |   |   | Before |
| 9/19/2011 | Sea | Teahen | Promoted to active roster |   |   | Before |
| 9/19/2011 | StL | Baker,S | Promoted to active roster |   |   | Before |
| 9/19/2011 | StL | Harang | Demoted to reserve roster |   |   | Before |
| 9/20/2011 | CWS | Garcia,F | Activated from disabled list |   |   | Before |
| 9/20/2011 | CWS | Garcia,F | Demoted to reserve roster |   |   | Before |
| 9/20/2011 | NYM | Helton | Promoted to active roster |   |   | Before |
| 9/20/2011 | NYM | Izturis,M | Placed on disabled list |   | 9/20/2011 | Before |
| 9/24/2011 | LA | Cantu | Demoted to reserve roster |   |   | Before |
| 9/24/2011 | LA | Tulowitzki | Activated from disabled list |   |   | Before |
| 9/28/2011 | Cin | Arrieta | Demoted to reserve roster |   |   | Before |
| 9/28/2011 | Cin | Pettitte | Activated from disabled list |   |   | Before |
| 10/1/2011 | StL | Schneider | Promoted to active roster |   |   | Before |
| 10/1/2011 | StL | Soto | Placed on disabled list |   | 10/1/2011 | Before |
| 10/2/2011 | NYY | Adams | Demoted to reserve roster |   |   | Before |
| 10/2/2011 | NYY | Garza | Demoted to reserve roster |   |   | Before |
| 10/2/2011 | NYY | Garza | Promoted to active roster |   |   | Before |
| 10/2/2011 | NYY | Halladay | Demoted to reserve roster |   |   | Before |
| 10/2/2011 | NYY | Slowey | Promoted to active roster |   |   | Before |
| 10/2/2011 | NYY | Wright,J | Promoted to active roster |   |   | Before |
| 10/4/2011 | ChC | Kennedy,I | Activated from disabled list |   |   | Before |
| 10/4/2011 | ChC | Stammen | Demoted to reserve roster |   |   | Before |
| 10/5/2011 | Bal | Belliard | Demoted to reserve roster |   |   | Before |
| 10/5/2011 | Bal | Nix,J | Activated from disabled list |   |   | Before |
| 10/5/2011 | NYM | Helton | Demoted to reserve roster |   |   | Before |
| 10/5/2011 | NYM | Izturis,M | Activated from disabled list |   |   | Before |